Global coalition to accelerate COVID-19 clinical research in resource-limited settings

by Global coalition to accelerate COVID-19 clinical research in resource-limited settings

To address challenges posed by the pandemic and accelerate the research needed in resource-limited settings, we propose an international research coalition that brings together existing multinational, multidisciplinary expertise and clinical trial capacity. The coalition will synergise with existing initiatives, such as the COVID-19 Therapeutics Accelerator, the Coalition for Epidemic Preparedness Innovations (CEPI), and the SARS-CoV-2 Diagnostic Pipeline. Our objective is to use our existing research capabilities to support, promote, and accelerate multicentre trials of the safety, efficacy, and effectiveness of interventions against COVID-19 in resource-limited settings. For therapeutics, research in such settings should focus primarily on evaluation of affordable repurposed medicines—ie, those already developed and approved for other indications—and implementable supportive measures. If applicable, testing of new diagnostic tools, vaccines, and other potentially beneficial strategies will be added to the trials.

26th January 2022 • comment

The COVID-19 Pandemic: Global Asymmetries and Challenges for the Future of Health

by Nísia Trindade Lima, Carlos Grabois Gadelha

Social  and  economic  inequality  between  countries, territories,  and  population  groups  has  increased  during the  pandemic.  Its  impacts  are  unevenly  distributed, revealing  the  interface  between  the  biological, economic,  and  social  worlds.  There  is  a  threat  of  a humanitarian  crisis  due  to  the  concrete  differences between  those  who  have  full  access  to  products, services,  and  health  and  those  who  can  be  left  behind.

26th January 2022 • comment

Non-communicable diseases: a challenge for global cooperation

by Nísia Trindade Lima e Carlos Gadelha

In current times, it’s easy to forget that over 70% of deaths worldwide are due to non-communicable diseases. How can we tackle their rise? The theory of epidemiological transition (or the changing patterns of population age distributions, mortality, fertility, life expectancy, and causes of death) offers a valuable framework for understanding how different types of diseases can occur simultaneously in a population. 

13th July 2021 • comment
14th April 2020 • comment